Florid cutaneous papillomatosis (FCP), also known as Schwartz-Burgess syndrome, is a rare, obligatory paraneoplastic disease characterized by the rapid and widespread eruption of verrucous, skin-colored papules that may be asymptomatic or pruritic. The lesions of FCP are clinically indistinguishable from human papillomavirus (HPV)-related verruca, but no viral particles are identified in the lesions.

FCP is most commonly associated with adenocarcinoma of gastrointestinal origin. Cancers of the lung, breast (male / female), bladder, liver and bile ducts, prostate, ovary, and uterus have also been associated with FCP. Typically, the disease course mirrors that of the underlying malignancy. The etiology of FCP has yet to be elucidated, although many studies have postulated the presence of a growth factor similar to human epidermal growth factor or transforming growth factor alpha, produced by the underlying malignancy.

FCP may occur with other paraneoplastic cutaneous markers including malignant acanthosis nigricans, Leser-Trélat sign, tripe palms, pachydermatoglyphy, palmoplantar keratoderma, and hypertrichosis lanuginosa acquisita.