Severe and rapidly rising blood pressure that can irreversibly damage the cardiovascular, renal, and nervous systems. Blood pressure over 180 (systolic) or 120 (diastolic), and sometimes lower, is considered a hypertensive emergency requiring immediate care. Other findings include headache, papilledema, impaired renal function, retinal hemorrhage, hypertensive encephalopathy, and microscopic hematuria. Less common in Western countries where antihypertensive medications are more commonly in use, it is mostly seen in underdeveloped nations and among immigrants.
Management requires appropriate response to hypertensive emergency, avoiding a too-rapid lowering of blood pressure. Treatments also depend on the extent and location of organ damage and presenting symptoms. Left untreated, prognosis is poor.
Malignant hypertension
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Synopsis

Codes
ICD10CM:
I10 – Essential (primary) hypertension
SNOMEDCT:
70272006 – Malignant hypertension
I10 – Essential (primary) hypertension
SNOMEDCT:
70272006 – Malignant hypertension
Differential Diagnosis & Pitfalls
- Essential hypertension
- Stroke
- Renal failure (acute, chronic)
- Renal artery stenosis
- Coarctation of the aorta
- Aortic dissection
- Preeclampsia / eclampsia
- Pheochromocytoma
- Hyperthyroidism
- Thrombotic thrombocytopenic purpura / hemolytic uremic syndrome
- Subarachnoid hemorrhage
- Hyperaldosteronism
- Cushing syndrome
- Vasculitis
- Drug-induced hypertension (eg, oral contraceptives, nonsteroidal anti-inflammatory drugs)
- Obstructive sleep apnea
- Acromegaly
- Increased intracranial pressure (see idiopathic intracranial hypertension)
Best Tests
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.
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References
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Last Updated:08/24/2023