Cryoglobulinemia is caused by globulins that undergo reversible precipitation from plasma or serum upon cooling. Type II and Type III cryoglobulins are mixed cryoglobulins that consist of a rheumatoid factor (IgM) complexed with either a monoclonal IgG (Type II) or a polyclonal IgG or non-immunoglobulin serum component (Type III). Mixed cryoglobulins are most commonly associated with hepatitis C and multiple systemic disorders. The organ systems involved include the skin, liver, kidneys, and the musculoskeletal and nervous systems. Lymphadenopathy, hepatomegaly, splenomegaly, arthritis, and arthralgias may be seen.